Eight clusters of long-covid symptoms

Introduction: Symptoms after covid are common. The clinical manifestation of long-covid was't described completely for the long term period. Aim(s): The aim was to describe veariety of patient's symptoms at least 4months after infection. Method(s): a)prepare questionnaire items;b)selection of relevant items;c)formal adjustment;d)pilot verification on 50pts;e)modification of the structure of questions;f)performing an exploratory factor analysis. Result(s): We enrolled 703consecutive pts(352 males;53+/-15yrs;BMI 29+/-5;222+/-112days from diagnosis)from Mar21 to Jan22. Two-fifths(272pts;39%)of them were initialy hospitalized due to covid. Eight clusters of long-covid symptoms/manifestations(s/m)were identified: respiratory+fatigue cluster;musculo-skeletal c.;skin c.;psychical c.;recurrent infections c.;smell+taste c.;trombotic c;nefrological c.Elderly pts were more affected by musculoskeletal s/m;less frequently experienced psychical s/m;recurrent infection s/m;small+taste s/m.Obese pts reported more frequently respiratory+fatigue s/m;musculo-skeletal s/m;thrombotic s/m;nephrological s/m. Educational level was not associated with the dominance of any s/m cluster. The Delta variant predisposed to the dominance of respiratory+fatigue s/m;musculo-skeletal s/m. Previously hospitalized suffered more frequently from musculo-skeletal s/m;trombotic s/m;less frequently from smell+taste s/m. Conclusion(s): Manifestation of long-covid symptoms is heterogeneous condition for many months after the initial diagnosis.

The long-COVID in the Czech Republic -interim analysis of population based survey

Introduction: The occurrence of the late effects of covid-19(long-covid)is a hot issue. Detailed data on its forms within the population are still lacking. Aim(s): We want to describe the long-covid in the population of the Czech Republic(CR)in relation to the covid severity. Method(s): Prospective collection of data on consecutive patients(pts)sent by GPs to pulmonologists started since June,21. The interim analysis concerns pts enrolled by February,22. The analysis was based on data collected in Information System of Infectious Diseases of the CR, especially its long-covid module. The 44 outpatient centers cover all 14regions of the CR and represent 13% of all(343)outpatient clinics of pulmonologists, they are responsible for the care of long-covid pts in the CR. Result(s): 3.489pts have been included in the study so far. After the removal of 40%pts with significant comorbidities,1.895"healthy"post-covid individuals (50%men,69%non-smokers)remained. Only a minority of these pts with long-covid 874(46%)were hospitalized due to covid severity. Inpatients were older, more often males/obese, less likely smokers. Inpatients had more severe post-covid residual CTchanges, more frequent diffusion capacity impairment, more restrictive ventilation pattern, and more oxygen desaturation during walking. Contrary nonhospitalized pts had more cough, and obstructive ventilation pattern. Hospitalized and non-hospitalized pts did not differ in incidence of resting desaturation, dyspnea, fatigue, expectoration, and chest pain. Despite the fact that 64%of the CR population is fully vaccinated, only 25(1.3%)were vaccinated among long-covid cohort. Conclusion(s): Previously hospitalized have more severe long-covid, however, most pts had only a mild acute COVID.

Post-COVID-19 syndrome/impairment. definition, diagnosis and classification. a brief position paper of the Czech Pneumological and Phthisiological Society (June 2021 update)

The Working Group of the Czech Pneumological and Phthisiological Society proposed a simple classification of post-COVID-19 patients into four originally established clinical groups. These groups (A-B-C-D) are based on the presence or absence of respiratory symptoms (dyspnea, cough, chest pain) and signs of pulmonary involvement (decreased Theo, latent respiratory insufficiency, lung impairment according to chest X-ray/HRCT) at least three months after COVID-19 diagnosis.